An integrated transcriptome analysis approach to characterise adult neural stem cells and study…

…complex disease
Alistair Chalk
Morning Session, 2 September (11th MGED Meeting, 1-4 September, 2008)

They use the hOSC model system to study complex neurological diseases. They use olfactory biopsies. There are adult stem cells in the nose, and they are multipotent. They do transcriptomic, phenotypic, genotypic, and epidemiological analyses. They want to characterize and compare these cells, and predict clinical outcome, among other things. They can detect differences between diseases from the exon array. There is concordance between individuals for the CAGE data. They can detect consistent transcription start site (TSS) events. The system is highy reproducible between many individuals, and there is concordance between expression datasets and donors. They can detect disease differences on multiple levels (transcript/exon/TSS).

These are just my notes and are not guaranteed to be correct.
Please feel free to let me know about any errors, which are all my
fault and not the fault of the speaker. 🙂

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